COMU is an uronium salt offering fast coupling that is very efficient, and almost no tendency for racemization. Using COMU appears to reduce the risk of Epimerization during coupling as compared to the use of HATU or HOBt. CAS No.: 1075198-30-9, MW: 428.27.

DIC is a useful reagent in SPPS because the urea by-product is more soluble in organic solvents and therefore more readily separated from the polymer support. Can be used in combination with OxymaPure. CAS No. : 693-13-0, MW: 126.2.

Peptide coupling agent with increased coupling efficiency and lower racemization compared to HATU. CAS No.: 958029-37-3, MW: 422.3.

HDMC has comparable coupling efficiency to HATU, reduced racemization level and high solubility. CAS No. : 1082951-62-9, MW: 455.72 g/mol.

K-Oxyma prevents premature cleavage of peptide-resins from extremely acid labile solid supports, such as the widely known CTC resin. Enhanced solubility in organic solvents, which is of great importance in the preparation of coupling mixtures.K-Oxyma shows higher thermal stability and a lower pressure release than parent benzotriazoles HOBt and HOAt.Compatible with carbodiimide-mediated solution and solid phase peptide coupling. Less epimerization than HOBt in fragment condensation reactions. CAS No.: 158014-03-0, MW: 180.2 g/mol.

OxymaPure is a highly efficient, non-explosive alternative to HOBt or HOAt, allowing high coupling rates at low racemization when applied in combination with carbodiimides. Oxyma Pure can be used in an identical manner as HOBt in DMF on automated synthesizers. CAS No. : 3849-21-6, MW: 142.11 g/mol